From:
Pittsburgh: I-279 North to I-79, to I-90, exit 24. (122 miles)
Buffalo: I-90 West to exit 24. (95 miles)
Cleveland: I-90 east to exit 24. (96 miles)
Philadelphia: I-76 West to I476 North, to I-80 West, to I-79 North, to I-90 East, exit 24. (414 miles)
New York City: I-280 West to I-80 West, to I-79 North, to I-90 East, exit 24. (425 miles)
Boston: I-90 West to New York State Thruway West, to I-87 North, to I-90 West, to I-88 West, to I-81 South, to RT-17 West, to I-86 West, to I-90 West, exit 24. (577 miles)
Exit 24 (Waterford): US-19 South to PA-97, to N Main St., to East High St., to West Smith Street Extension, to West Smith Street, to North Center Street. 29 miles
Erie International Airport: West 12 Street to Powell Avenue, to West 26th Street, to I-79 South, to Interchange Road, to Peach Street, to PA-97, to North Main Street, to East High Street, to US-6, to West Smith Street Extension, to West Smith Street, to North center Street. (37 miles)
From Mercyhurst Corry campus to Erie campus:
Park Place to West Smith Street, to West Smith Street Extension, to US-6, to Beaverdam Road, to PA-89, to PA-8, to East 38th Street. (30 miles)